![]() ![]() In our previous published work, we have evaluated the use of allometry for prediction of CL/F and AUC. Allometric scaling is a widely used methodology in the pharmaceutical industry to predict human pharmacokinetic parameters such as clearance and volume of distribution. The C(max) and t(½) following oral drug administration are functions of the oral clearance (CL/F) and apparent volume of distribution during the terminal phase by the oral route (V(z)/F), each of which may be predicted and combined to estimate C(max) and t(½). Such pharmacokinetic properties include suitable peak (maximum) plasma drug concentration ( C(max)), area under the plasma concentration-time curve (AUC) and a suitable half-life (t(½)). ![]() It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin and convenient dosing regimens in clinical practice, which then lead to better patient compliance. Sinha, Vikash K Vaarties, Karin De Buck, Stefan S Fenu, Luca A Nijsen, Marjoleen Gilissen, Ron A H J Sanderson, Wendy Van Uytsel, Kelly Hoeben, Eva Van Peer, Achiel Mackie, Claire E Smit, Johan W Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.
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